Bolsa de TT-3 em Bioquímica

TT-3 fellowship in Biochemistry

• Resumo Summary

  BOLSA TT-3: Clonagem e expressão de proteínas quinases - Structural Genomics Consortium.

  A bolsa está vinculada a um projeto de química medicinal no modelo de ciência aberta. O projeto será desenvolvido na Unicamp-SGC (thesgc.org), laboratório internacional com objetivo de desenvolver moléculas inibidoras de proteínas quinases humanas.

  Esse ambiente muito estimulante e com possiblidade de crescimento acadêmico está procurando candidatos com noções básicas de clonagem, expressão e purificação de proteínas. Também se espera que o candidato saiba interagir em grupo e auxiliar tarefas gerais do laboratório.

  Público-alvo: alunos formados em áreas químicas e biológicas, principalmente, mas não restrito a, Farmácia, Biologia, Química, Biotecnologia e Medicina.

  Enviar link do CV lattes e dois parágrafos descrevendo o interesse na vaga para sgc.unicamp.applications@gmail.com.

  The >500 protein kinases in the human genome are key regulators of virtually every physiological process. Kinases can be targeted by highly potent and selective small molecules. However, despite their importance and suitability for drug discovery, most academic and pharmaceutical research has focused on a small fraction of kinases; most kinases are "under-explored". These under-explored kinases represent a rich source of new biology and are the focus of this proposal.

  At UNICAMP, we propose to combine the strengths of academia and industry to generate selective small molecule inhibitors ("chemical probes") for under-explored kinases implicated in the regulation of RNA splicing and chromatin biology. There is emerging evidence linking these kinases to neurological diseases, angiogenesis, and cancer. To accomplish this, we will establish a "structure-guided medicinal chemistry" platform at UNICAMP, with funding and advice from our eight pharmaceutical partners and an external advisory board comprising leaders in chemical biology.
  
  Our platform will generate chemical probes for each kinase, and characterize the probes in biochemical assays to establish potency and selectivity, and in cellular assays to demonstrate "on-target engagement" in cells. Once the chemical probes meet our stringent quality criteria, we will make them available to Brazilian and international scientists without restriction on use. The availability of these chemical probes will uncover new biological pathways and identify new opportunities for therapeutic intervention. By establishing this open access chemistry platform at UNICAMP, we hope to establish UNICAMP as one of the world centers of kinase chemical biology.