Bolsa de PD em Química

Post doctoral fellowship in Chemistry

• Resumo Summary

  O conceito de imitância eletroquímica foi recentemente desenvolvido pela Universidade Estadual Paulista (Unesp) e a Universidade de Oxford e resultou em patentes e trabalhos publicados. 
  
  Ele permite a detecção ultrasensível e não marcada de importantes alvos clínicos e afinidade biológica. Com esta plataforma superfícies transdutoras biofuncionalizadas (em uma plataforma multicanal ou não) podem ser geradas usando ligantes como alvos específicos e clinicamente importantes para detecção de proteínas associadas com doenças e desordens patológicas. 
  
  O principal propósito deste projeto é continuar a desenvolver o conceito e explorar sua aplicabilidade em pacientes do Reino Unido e do Brasil.
  
  Para mais informações e interesse na vaga, enviar CV e carta de interesse para: 
  
  Prof. Dr. Paulo R. Bueno 
  UNESP, São Paulo State University 
  Institute of Chemistry, Physical Chemistry Department 
  Personal Home Page Nanobionics Group: www.nanobionics.pro.br.

  It is based on development of a completely new platform technology based on an entirely novel electrochemical impedance analysis; for use in diagnostics, prognostics or other analyte detection (environmental, food, etc). 
  
  The analysis is entirely label free, exceedingly sensitive and high-throughput. In optimizing the detection of each biomarker, surface conditions are initially optimized and the interface then sampled by frequency-resolved impedance (in an entirely standard manner, with the electrode arrays coupled to a multiplexer and then to a potentiostat). 
  
  The acquired signal is then processed using a patented method such that a number of Immittance Functions (mathematically related to impedance) are generated across that same frequency range and in the presence of difference concentrations of target. 
  
  The volume of data generated, then, is considerably greater than in a standard impedance assay. From all of the functions, that which is most respo nsive at an optimized sampling frequency is selected and then used to generate an analytical curve. 
  
  Preliminary work has already shown that this methodology is highly effective where standard impedance methods fail. It is not model-specific, target or receptor specific. It is readily applicable within a point-of-care device (supporting personalized medicine, use in or away from the clinic) and is designed to be “plug and play” in the sense that no prior knowledge is required. 
  
  The sample volume requirements are minimal (a few tens of microliters) and the limits of detection down to the femtomolar regime (across a linear range typically several orders of magnitude).
  
  For more details and interest to apply send your CV and a letter of interest to: 
  
  Prof. Dr. Paulo R. Bueno 
  UNESP, São Paulo State University 
  Institute of Chemistry, Physical Chemistry Department 
  Personal Home Page Nanobionics Group: www.nanobionics.pro.br