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BIOTA-FAPESP International Workshop on Metabolomics in the Context of Systems Biology (Feb 25 and 26/2010)

The BIOTA-FAPESP International Workshop on Metabolomics in the Context of Systems Biology: a rational approach to search for lead molecules from nature will be presented at FAPESP's building on February 25 and 26, 2010.


February 25
8h00 - Registration

08h40 - Open Ceremony

Symposium I: Metabolomics and Systems biology as a tool for new drugs discovery

9h00 - Systems Biology: a Gateway to Novel Discoveries - Robert Verpoorte, Leiden University, Holland

9h50 - Integration of Structure and Ligands Based Drug Design Approaches for the Discovery of Lead Compounds from Natural Products - Adriano Andricopulo, USP, São Carlos, SP

10h15 - Inhibition of Photophosphorylation and Electron Transport Chain in Thylakoids by Natural Products - Maria Fátima das G. Fernandes da Silva, UFSCAR, São Carlos, SP

10h40 - The Development of New Products from Brazilian Biodiversity - Emerson Queiroz, Laboratório Aché, São Paulo, SP

11h05 - Coffee Break

11h20 - MS-based Metabolomic Approaches Combined with Microflow-NMR Methods for the Search of Original Stress Induced Biomarkers in Plants - Jean-Luc Wolfender, Université de Genève

12h10 - Discussion

12h30 - Lunch Time (restaurants around FAPESP)

Symposium II: Plants and Associate Microorganisms as Potential source of New Biologically Active Molecules

14h00 - Systems Biology of Symbiotic Bacteria and the Search for New Biologically Active Molecules- Jon Clardy, Harvard Medical School, USA

14h50 - Exploring Microbial Interactions in Natural Products Research- Monica Talarico Puppo, USP, Ribeirão Preto, SP

15h15 - Search for Potential Antitumoral, Antioxidant, Anti-inflammatory, Antifungal, Antidiabetic, Acetylcholinesterase and Myeloperoxidase Inhibitory Natural Compounds from Cerrado and Atlantic Forest - Dulce Helena Siqueira Silva, UNESP, Araraquara, SP

15h40 - Coffee Break

16h00 - Footprinting of the ‘Final-fate Compounds’ in Systems Biology: Reading the Nature’s Message- Mario Palma, UNESP, Rio Claro, SP

16h25 - Molecular diversity among basal Angiosperms - Massuo Jorge Kato, USP, São Paulo, SP

16h50 - Cultured Cyanobacteria: A Promising Source for Novel Bioactive Natural Products - Jimmy Orjala, University of Illinois at Chicago, USA

17h40 - Discussion

February 26
Symposium III: New Advance Methodology for the Search Drug Discovery

9h00 - New Advance Methodology for the Search Drug Discovery- Arthur Edison, University of Florida, USA

9h50 - ESI-MS/MS Techniques and Applications for the Analysis of Natural Products- Norberto Peporine Lopes, USP, Ribeirão Preto,SP

10h15 - ISearch to be applied in enantioselective oxidation of secondary alcohols and bioreduction of ketones - Leandro Helgueira Andrade, USP, São Paulo, SP

10h40 - Novel application of 2D and 3D-similarity searches to assess compound selectivity among Cytochrome P450 2C9, 2D6 and 3A4 substrates - Carlos Alberto Montanari, USP, São Carlos, SP

11h05 - Coffee Break

11h30 - Innovative Strategies to Enhance Structural Diversity of Natural Products and Discovery of their New Uses - A. A. Leslie Gunatilaka, The University of Arizona, USA

12h20 - Discussion

12h40 - Lunch Time (restaurants around FAPESP)

Symposium IV: New Approach to Screening Biodiversity Source Materials and New Trends in Pharmacology and Toxicology to Select New Targets

14h00 - Taxol, Tubulin and Tumors: Challenges in the New Era of Cancer Therapeutics- Suzan Band Horwitz, Albert Einstein College of Medicine, USA

14h50 - Signaling through acetylcholine: multiple targets, phylogenetic conser- vation, and rich pharmacology- Newton G. Castro, UFRJ, Rio de Janeiro

15h20 - Decoding the Signaling Network in Malaria Parasites - Célia Regina Silva Garcia, USP, São Paulo, SP

15h50- Recent Studies of Natural Products Isolated from Brazilian Plants: Evaluation of Antigenotoxicity, Antimutagenicity and Antitumoral Assays - Christiane Pienna Soares, UNESP, Araraquara, SP

16h15 - Coffee break

16h30 - Novel Heparinomimetics with Potential Therapeutic Use in Cardiovascular and Inflammatory Disorders - Helena B. Nader, UNIFESP, SP

17h00 - Discussion

Close Remarks

17h30 - Vanderlan da Silva Bolzani, UNESP, Araraquara, SP

Rua Pio XI, 1500 – Alto da Lapa - São Paulo – SP
Parking suggestion: Taticar, R. Jorge Americano, 89

Information: (11) 3838-4006/3838-4216 -